[{"_1":2,"_3":-5,"_4":-5},"loaderData",{"_5":6,"_7":8},"actionData","errors","root",{"_26":27,"_28":29,"_30":12,"_31":12,"_32":12,"_33":12,"_34":12,"_35":12,"_36":37},"routes/canvas.shared.$sharedTextdocId",{"_9":10,"_11":12},"sharedTextdoc",{"_13":14,"_15":-7,"_16":17,"_18":19,"_20":21,"_22":23,"_24":12,"_25":12},"isAuthenticated",false,"sharedTextdocId","69007c5235b88191b69c794bb31ddaee","versionInt","title","Interactive Webpage – Tsh Cluster Review","type","code/react","content","import React, { useMemo, useState } from \"react\";\nimport { motion } from \"framer-motion\";\nimport { Search, Star, ChevronDown, ChevronUp, Copy } from \"lucide-react\";\nimport { Button } from \"@/components/ui/button\";\nimport { Card, CardContent, CardDescription, CardHeader, CardTitle } from \"@/components/ui/card\";\nimport { Input } from \"@/components/ui/input\";\nimport { Badge } from \"@/components/ui/badge\";\nimport { Switch } from \"@/components/ui/switch\";\n\n// Helper: stars\nconst Stars = ({ n }: { n: number }) => (\n

\n {Array.from({ length: n }).map((_, i) => (\n \n ))}\n

\n);\n\n// Q&A accordion item\nfunction QAItem({ q, a, tip, tag, strength, suggested, defaultOpen = false }: any) {\n const [open, setOpen] = useState(defaultOpen);\n return (\n \n setOpen((o) => !o)}\n className=\"w-full text-left\"\n aria-expanded={open}\n aria-controls={`ans-${q}`}\n >\n \n

\n \n {q}\n {suggested && (\n Suggested Q&A\n )}\n \n \n Evidence strength:\n \n {tag}\n \n

\n {open ? : }\n

\n \n \n {open && (\n \n

\n {tip && (\n

Tip: {tip}

\n )}\n \n )}\n \n );\n}\n\n// Summary rows (kept for future table if needed)\nconst SUMMARY_ROWS = [\n { approach: \"Sleep / Circadian\", strength: 1, effect: \"Minor variation\", key: \"Maintain regular sleep timing\" },\n { approach: \"Psychosocial / CBT\", strength: 1, effect: \"Possible normalization\", key: \"Stress-mediated only\" },\n { approach: \"Stress Reduction\", strength: 1, effect: \"Transient suppression\", key: \"Indirect benefits\" },\n { approach: \"Exercise\", strength: 2, effect: \"Variable ↑TSH acutely\", key: \"Supports metabolic health\" },\n { approach: \"Diet (Iodine/Selenium)\", strength: 3, effect: \"Normalization\", key: \"Strongest evidence\" },\n { approach: \"Multicomponent Programs\", strength: 2, effect: \"Modest improvement\", key: \"Lifestyle adjunct\" },\n];\n\nexport default function TSHClusterReviewPage() {\n const [query, setQuery] = useState(\"\");\n const [showSuggested, setShowSuggested] = useState(true);\n const [minStars, setMinStars] = useState(0);\n\n // Full dataset: real + suggested Q&As\n const DATA = useMemo(\n () => [\n // REAL Q&As\n {\n q: \"Is there a link between sleep and TSH?\",\n a: [\n \"Short-term sleep deprivation increases nocturnal TSH; chronic poor sleep may blunt its rhythm.\",\n \"Shift work and irregular sleep schedules can cause minor lab fluctuations.\",\n \"No strong data show that improving sleep normalizes abnormal TSH.\",\n ],\n tip: \"Maintain a regular sleep–wake cycle to stabilize circadian hormone patterns.\",\n tag: \"Sleep / Circadian\",\n strength: 1,\n suggested: false,\n },\n {\n q: \"Is there any evidence that psychosocial interventions can affect TSH levels?\",\n a: [\n \"Small studies show normalization of TSH after stress-management or CBT in stress-related disorders.\",\n \"Mechanism likely via reduced cortisol and hypothalamic activation, not direct thyroid effects.\",\n \"No large RCTs in thyroid disease populations.\",\n ],\n tip: \"Psychosocial support improves wellbeing but is not a substitute for thyroid therapy.\",\n tag: \"Psychosocial / CBT\",\n strength: 1,\n suggested: false,\n },\n {\n q: \"Are there any CBT or other psychosocial interventions that have an effect on TSH levels?\",\n a: [\n \"Findings mirror broader psychosocial evidence: small studies suggest possible TSH normalization via stress pathway modulation.\",\n \"Heterogeneous populations and short durations limit certainty.\",\n ],\n tag: \"Psychosocial / CBT\",\n strength: 1,\n suggested: false,\n },\n {\n q: \"Is there a link between exercise and TSH?\",\n a: [\n \"Acute exercise temporarily raises TSH and thyroid hormones.\",\n \"Chronic moderate training may improve thyroid sensitivity; effects vary by intensity and baseline status.\",\n ],\n tip: \"Combine aerobic and resistance exercise for overall endocrine and metabolic health.\",\n tag: \"Exercise\",\n strength: 2,\n suggested: false,\n },\n {\n q: \"What lifestyle interventions can be used to treat abnormal TSH levels?\",\n a: [\n \"No single lifestyle program reliably normalizes abnormal TSH.\",\n \"Combined approaches (diet, exercise, stress reduction) improve general metabolic markers; TSH shifts are usually small and within normal limits.\",\n \"Lifestyle change should support, not replace, medical management.\",\n ],\n tag: \"Multicomponent\",\n strength: 2,\n suggested: false,\n },\n\n // SUGGESTED Q&As\n {\n q: \"Do circadian rhythm interventions (e.g., light therapy or regular sleep timing) influence TSH secretion?\",\n a: [\n \"Consistent schedules and light exposure likely stabilize TSH rhythms via circadian alignment.\",\n \"Controlled trials specifically demonstrating TSH normalization are lacking.\",\n ],\n tag: \"Sleep / Circadian\",\n strength: 1,\n suggested: true,\n },\n {\n q: \"Does chronic stress or cortisol dysregulation affect TSH levels?\",\n a: [\n \"Chronic stress and elevated cortisol can transiently suppress TSH and T3.\",\n \"Effects are typically reversible and not linked to persistent hypothyroidism.\",\n ],\n tip: \"Regular relaxation and mindfulness may indirectly stabilize thyroid function.\",\n tag: \"Stress\",\n strength: 1,\n suggested: true,\n },\n {\n q: \"Is diet quality or specific nutrients (iodine, selenium, vitamin D) associated with TSH regulation?\",\n a: [\n \"Adequate iodine and selenium are essential; deficiency or excess iodine can elevate TSH.\",\n \"Vitamin D may influence autoimmunity more than TSH directly.\",\n ],\n tip: \"Balanced diet with adequate iodine/selenium supports optimal thyroid function.\",\n tag: \"Diet / Nutrients\",\n strength: 3,\n suggested: true,\n },\n {\n q: \"Can weight loss or metabolic improvement normalize TSH in subclinical hypothyroidism?\",\n a: [\n \"Weight loss (~5–10%) in obesity can normalize mildly elevated TSH, likely via improved leptin and inflammatory signaling.\",\n ],\n tag: \"Diet / Nutrients\",\n strength: 3,\n suggested: true,\n },\n {\n q: \"Are changes in TSH through behavioral interventions clinically meaningful (e.g., linked to symptom improvement or fT4/fT3)?\",\n a: [\n \"Observed TSH shifts after lifestyle interventions are usually within normal variation.\",\n \"Meaningful changes in free T4/T3 or symptoms are uncommon in the absence of thyroid disease.\",\n ],\n tag: \"Multicomponent\",\n strength: 2,\n suggested: true,\n },\n ],\n []\n );\n\n const filtered = useMemo(() => {\n const qLower = query.toLowerCase().trim();\n return DATA.filter((item: any) =>\n (showSuggested || !item.suggested) &&\n item.strength >= minStars &&\n (qLower.length === 0 || `${item.q} ${item.a.join(' ')}`.toLowerCase().includes(qLower))\n );\n }, [query, minStars, showSuggested, DATA]);\n\n return (\n

\n {/* Header */}\n \n

\n Lifestyle, Psychosocial, and Behavioral Influences on TSH Levels (2025)\n

\n Synthesised cluster review combining real Q&As with suggested additions. Click a question to reveal the answer.\n

\n \n\n {/* Controls */}\n

\n \n setQuery(e.target.value)}\n placeholder=\"Search questions or answers (e.g. sleep, iodine, CBT)…\"\n className=\"border-0 focus-visible:ring-0\"\n />\n

\n Show suggested Q&As\n \n

\n Minimum evidence\n

\n {[0,1,2,3].map((n) => (\n \n ))}\n

\n\n {/* Q&A list */}\n

\n {filtered.map((item: any, idx: number) => (\n \n ))}\n {filtered.length === 0 && (\n

No questions match your filters.

\n )}\n

\n );\n}\n","access","public","isModerationBlocked","isAnonifyApiKeyDetected","dd",{"_38":39,"_40":41},"disablePrefetch",true,"shouldPrefetchAccount","shouldPrefetchUser","shouldPrefetchSystemHints","promoteCss","disableSSR","stripModulepreloadImports","statsigGateEvaluationsPromise",["P",37],"traceId","3975503556699123549","traceTime",1779498478123]