In Vivo Gene Editing in Ongoing Human Clinical Trials

Content may be unverified or unsafe. Report
ChatGPT
Citations

CRISPR Clinical Trials: A 2024 Update

https://trial.medpath.com/news/00f1828bfcf889e0/crispr-clinical-trials-a-2024-update

Frontiers | CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders

https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1553590/full

Review Explores CRISPR Delivery Methods in Therapy

https://crisprmedicinenews.com/news/review-explores-crispr-delivery-methods-in-therapy/

Review Explores CRISPR Delivery Methods in Therapy

https://crisprmedicinenews.com/news/review-explores-crispr-delivery-methods-in-therapy/

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

Frontiers | CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders

https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1553590/full

Frontiers | CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders

https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1553590/full

Frontiers | CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders

https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1553590/full

First Patient Treated with Sangamo In Vivo Genome Editing Therapeutic

https://www.insideprecisionmedicine.com/news-and-features/first-patient-treated-with-sangamo-in-vivo-genome-editing-therapeutic/

Sangamo sinks as genome editing flunks early clinical test

https://www.fiercebiotech.com/biotech/sangamo-sinks-as-genome-editing-flunks-early-clinical-test

Sangamo's shares fall on mixed early data from study of gene ...

https://firstwordpharma.com/story/4647651

Participants of pioneering CRISPR gene editing trial see vision improve | National Eye Institute

https://www.nei.nih.gov/about/news-and-events/news/participants-pioneering-crispr-gene-editing-trial-see-vision-improve

Participants of pioneering CRISPR gene editing trial see vision improve | National Eye Institute

https://www.nei.nih.gov/about/news-and-events/news/participants-pioneering-crispr-gene-editing-trial-see-vision-improve

Frontiers | CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders

https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1553590/full

CRISPR-Based In Vivo Gene Editing via Optimized LNP and AAV ...

https://www.linkedin.com/pulse/crispr-based-vivo-gene-editing-via-optimized-lnp-aav-huang-md-phd-j9rqe

CRISPR Gene Therapy Durably Reduces TTR in Patients With ATTR Amyloidosis

https://www.cgtlive.com/view/crispr-gene-therapy-reduces-ttr-attr-amyloidosis

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

CRISPR Gene Therapy Durably Reduces TTR in Patients With ATTR Amyloidosis

https://www.cgtlive.com/view/crispr-gene-therapy-reduces-ttr-attr-amyloidosis

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

China’s First In Vivo Gene Editing Drug Administered to First ATTR Patient at PUMCH - 北京协和医院 - 协和医院,北京协和医院,協和醫院,北京协和医院首页,北京协和医院电话,协和,協和,医院,醫院,北京協和醫院,北京协和医院妇科,北京协和医院地址,挂号

https://www.pumch.cn/en/detail/37005.html

China’s First In Vivo Gene Editing Drug Administered to First ATTR Patient at PUMCH - 北京协和医院 - 协和医院,北京协和医院,協和醫院,北京协和医院首页,北京协和医院电话,协和,協和,医院,醫院,北京協和醫院,北京协和医院妇科,北京协和医院地址,挂号

https://www.pumch.cn/en/detail/37005.html

Intellia Therapeutics Announces Positive Long-Term Data

https://www.globenewswire.com/news-release/2024/06/02/2891838/0/en/Intellia-Therapeutics-Announces-Positive-Long-Term-Data-from-Ongoing-Phase-1-Study-of-NTLA-2002-an-Investigational-In-Vivo-CRISPR-Gene-Editing-Treatment-for-Hereditary-Angioedema-H.html

Intellia Therapeutics Announces Positive Long-Term Data

https://www.globenewswire.com/news-release/2024/06/02/2891838/0/en/Intellia-Therapeutics-Announces-Positive-Long-Term-Data-from-Ongoing-Phase-1-Study-of-NTLA-2002-an-Investigational-In-Vivo-CRISPR-Gene-Editing-Treatment-for-Hereditary-Angioedema-H.html

Intellia Therapeutics Announces Positive Long-Term Data

https://www.globenewswire.com/news-release/2024/06/02/2891838/0/en/Intellia-Therapeutics-Announces-Positive-Long-Term-Data-from-Ongoing-Phase-1-Study-of-NTLA-2002-an-Investigational-In-Vivo-CRISPR-Gene-Editing-Treatment-for-Hereditary-Angioedema-H.html

Intellia Therapeutics Announces Positive Long-Term Data

https://www.globenewswire.com/news-release/2024/06/02/2891838/0/en/Intellia-Therapeutics-Announces-Positive-Long-Term-Data-from-Ongoing-Phase-1-Study-of-NTLA-2002-an-Investigational-In-Vivo-CRISPR-Gene-Editing-Treatment-for-Hereditary-Angioedema-H.html

Intellia Therapeutics Announces Positive Long-Term Data

https://www.globenewswire.com/news-release/2024/06/02/2891838/0/en/Intellia-Therapeutics-Announces-Positive-Long-Term-Data-from-Ongoing-Phase-1-Study-of-NTLA-2002-an-Investigational-In-Vivo-CRISPR-Gene-Editing-Treatment-for-Hereditary-Angioedema-H.html

Intellia Therapeutics Announces Positive Long-Term Data

https://www.globenewswire.com/news-release/2024/06/02/2891838/0/en/Intellia-Therapeutics-Announces-Positive-Long-Term-Data-from-Ongoing-Phase-1-Study-of-NTLA-2002-an-Investigational-In-Vivo-CRISPR-Gene-Editing-Treatment-for-Hereditary-Angioedema-H.html

Intellia Therapeutics Announces Positive Long-Term Data

https://www.globenewswire.com/news-release/2024/06/02/2891838/0/en/Intellia-Therapeutics-Announces-Positive-Long-Term-Data-from-Ongoing-Phase-1-Study-of-NTLA-2002-an-Investigational-In-Vivo-CRISPR-Gene-Editing-Treatment-for-Hereditary-Angioedema-H.html

Participants of pioneering CRISPR gene editing trial see vision improve | National Eye Institute

https://www.nei.nih.gov/about/news-and-events/news/participants-pioneering-crispr-gene-editing-trial-see-vision-improve

Editas to seek partner for CRISPR medicine after lackluster study ...

https://www.biopharmadive.com/news/editas-pause-study-partner-lca-crisp-gene-editing/636814/

Editas Reports Results for 14 Participants in its Phase 1/2 CRISPR ...

https://www.fightingblindness.org/news/editas-reports-results-for-14-participants-in-its-phase-1-2-crispr-cas9-clinical-trial-for-lca10-852

Editas to seek partner for CRISPR medicine after lackluster study ...

https://www.biopharmadive.com/news/editas-pause-study-partner-lca-crisp-gene-editing/636814/

Clinical trial: Human papillomavirus (HPV) related Cervical Cancer, (NCT03057912) - CRISPR Medicine

https://crisprmedicinenews.com/clinical-trial/human-papillomavirus-hpv-related-cervical-cancer-nct03057912/

Clinical trial: Human papillomavirus (HPV) related Cervical Cancer, (NCT03057912) - CRISPR Medicine

https://crisprmedicinenews.com/clinical-trial/human-papillomavirus-hpv-related-cervical-cancer-nct03057912/

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

Verve Therapeutics’ Base Editing Therapy VERVE-102 Reduces LDL-C in Patients With HeFH and CAD

https://www.cgtlive.com/view/verve-therapeutics-base-editing-therapy-verve-102-reduces-ldl-c-patients-hefh-cad

Verve Therapeutics’ Base Editing Therapy VERVE-102 Reduces LDL-C in Patients With HeFH and CAD

https://www.cgtlive.com/view/verve-therapeutics-base-editing-therapy-verve-102-reduces-ldl-c-patients-hefh-cad

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

Verve Therapeutics’ Base Editing Therapy VERVE-102 Reduces LDL-C in Patients With HeFH and CAD

https://www.cgtlive.com/view/verve-therapeutics-base-editing-therapy-verve-102-reduces-ldl-c-patients-hefh-cad

Verve Therapeutics’ Base Editing Therapy VERVE-102 Reduces LDL-C in Patients With HeFH and CAD

https://www.cgtlive.com/view/verve-therapeutics-base-editing-therapy-verve-102-reduces-ldl-c-patients-hefh-cad

Verve Therapeutics’ Base Editing Therapy VERVE-102 Reduces LDL-C in Patients With HeFH and CAD

https://www.cgtlive.com/view/verve-therapeutics-base-editing-therapy-verve-102-reduces-ldl-c-patients-hefh-cad

News: Excision’s EBT-101 Demonstrates Safety in Clinical Trial But Does Not Cure HIV - CRISPR Medicine

https://crisprmedicinenews.com/news/excisions-ebt-101-demonstrates-safety-in-clinical-trial-but-does-not-cure-hiv/

News: Excision’s EBT-101 Demonstrates Safety in Clinical Trial But Does Not Cure HIV - CRISPR Medicine

https://crisprmedicinenews.com/news/excisions-ebt-101-demonstrates-safety-in-clinical-trial-but-does-not-cure-hiv/

2024 HIV Cure Update: Breakthroughs, Challenges, and Future ...

https://insti.com/2024-hiv-cure-update-breakthroughs-challenges-and-future-research/?srsltid=AfmBOopoJYK9U7gw-HtJb8z6AUgFwjCOOLwFa2rbh3eXuSid-KqPtkBA

CRISPR gene therapy EBT-101 does not prevent HIV viral rebound

https://www.aidsmap.com/news/may-2024/crispr-gene-therapy-ebt-101-does-not-prevent-hiv-viral-rebound

HIV cure: ending the HIV epidemic | ViiV Healthcare

https://viivhealthcare.com/ending-hiv/towards-a-hiv-cure/

Excision BioTherapeutics Announces Oral Presentation at the 2024 ...

https://www.excision.bio/news/press-releases/detail/46/excision-biotherapeutics-announces-oral-presentation-at-the

CRISPR Clinical Trials: A 2024 Update

https://trial.medpath.com/news/00f1828bfcf889e0/crispr-clinical-trials-a-2024-update

News: Locus Biosciences Shares Positive Phase 2 Data for CRISPR ...

https://crisprmedicinenews.com/news/locus-biosciences-shares-positive-phase-2-data-for-crispr-edited-phage-treatment-for-urinary-tract-i/

Locus Biosciences Announces Positive Results from Part 1 of ELIMINATE Phase 2 Trial of the Engineered Bacteriophage Therapy LBP-EC01 Published in The Lancet Infectious Diseases - Locus Bioscience

http://www.locus-bio.com/locus-biosciences-announces-positive-results-from-part-1-of-eliminate-phase-2-trial-of-the-engineered-bacteriophage-therapy-lbp-ec01-published-in-the-lancet-infectious-diseases/

Locus Biosciences Announces Positive Results from Part 1 of ELIMINATE Phase 2 Trial of the Engineered Bacteriophage Therapy LBP-EC01 Published in The Lancet Infectious Diseases - Locus Bioscience

http://www.locus-bio.com/locus-biosciences-announces-positive-results-from-part-1-of-eliminate-phase-2-trial-of-the-engineered-bacteriophage-therapy-lbp-ec01-published-in-the-lancet-infectious-diseases/

World's-first clinical trial for a CRISPR-Cas3 phage therapy. Interview

https://crisprmedicinenews.com/news/worlds-first-clinical-trial-for-a-crispr-cas3-phage-therapy-interview-joseph-nixon-locus-bioscie/

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

Personalized CRISPR Gene Therapy Used in Historic Treatment | Technology Networks

https://www.technologynetworks.com/biopharma/news/infant-treated-with-worlds-first-personalized-gene-editing-therapy-399803

Personalized CRISPR Gene Therapy Used in Historic Treatment | Technology Networks

https://www.technologynetworks.com/biopharma/news/infant-treated-with-worlds-first-personalized-gene-editing-therapy-399803

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

The Baby, the Base Editor, and the Breakthrough: How Scientists Fixed a Gene in Just Six Months — Veritas Innovation

https://www.veritasinnovation.com/blog-archive/the-baby-the-base-editor-and-the-breakthrough-how-scientists-fixed-a-gene-in-just-six-months

Sangamo sinks as genome editing flunks early clinical test

https://www.fiercebiotech.com/biotech/sangamo-sinks-as-genome-editing-flunks-early-clinical-test

Sangamo sinks as genome editing flunks early clinical test

https://www.fiercebiotech.com/biotech/sangamo-sinks-as-genome-editing-flunks-early-clinical-test

YolTech Therapeutics to Initiate a Clinical Trial for YOLT-204, a First ...

https://www.biospace.com/press-releases/yoltech-therapeutics-to-initiate-a-clinical-trial-for-yolt-204-a-first-in-class-bone-marrow-targeted-in-vivo-gene-editing-therapy-for-%CE%B2-thalassemia

Chinese startup begins first trial of in vivo CRISPR therapy for blood ...

https://endpts.com/chinese-startup-begins-first-clinical-trial-using-crispr-to-edit-cells-directly-in-the-bone-marrow/

YolTech Therapeutics Announces Positive Clinical Data for YOLT ...

https://www.prnewswire.com/news-releases/yoltech-therapeutics-announces-positive-clinical-data-for-yolt-203-an-in-vivo-gene-editing-therapy-for-primary-hyperoxaluria-type-1-ph1-302384408.html

In vivo hematopoietic stem cell modification by mRNA delivery

https://www.science.org/doi/10.1126/science.ade6967

The promise of in vivo HSC prime editing | Blood - ASH Publications

https://ashpublications.org/blood/article/141/17/2039/495427/The-promise-of-in-vivo-HSC-prime-editing

CRISPR Clinical Trials: A 2024 Update

https://trial.medpath.com/news/00f1828bfcf889e0/crispr-clinical-trials-a-2024-update

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

Intellia’s Phase 3 Clinical Trial for CRISPR-Based Gene Therapy Enrolls First Patient

https://www.cgtlive.com/view/intellia-phase-3-clinical-trial-crispr-based-gene-therapy-enrolls-first-patient

Personalized CRISPR Gene Therapy Used in Historic Treatment | Technology Networks

https://www.technologynetworks.com/biopharma/news/infant-treated-with-worlds-first-personalized-gene-editing-therapy-399803

Yair Einhorn - X

https://x.com/yaireinhorn/status/1797242091291959407

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

News: Clinical Update: First Trial of Base-Editing Therapy Lowers Cholesterol in Humans - CRISPR Medicine

https://crisprmedicinenews.com/news/clinical-update-first-trial-of-base-editing-therapy-lowers-cholesterol-in-humans/

Advancements in Gene Editing and Clinical Trials - MedPath

https://trial.medpath.com/news/a72bacd989114b85/cmn-weekly-8-november-2024-your-weekly-crispr-medicine-news

CRISPR Clinical Trials: A 2024 Update

https://trial.medpath.com/news/00f1828bfcf889e0/crispr-clinical-trials-a-2024-update

CRISPR Clinical Trials: A 2024 Update

https://trial.medpath.com/news/00f1828bfcf889e0/crispr-clinical-trials-a-2024-update

CRISPR Clinical Trials: A 2024 Update

https://trial.medpath.com/news/00f1828bfcf889e0/crispr-clinical-trials-a-2024-update

Frontiers | CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders

https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1553590/full

Frontiers | CRISPR-dependent base editing as a therapeutic strategy for rare monogenic disorders

https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1553590/full